2. Signaling Pathways
  3. PROTAC
  4. Ligands for E3 Ligase
  5. Ligands for E3 Ligase Substrate

Ligands for E3 Ligase Substrate

Ligands for E3 Ligase Isoform Comparison

Ligands for E3 Ligase Substrate (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-183988
    OICR409946
    OICR409946 is a self-dimerization-induced proximity-targeting chimera (SDIPTAC) targeting DCAF1, with a Kd value of 6200 nM. OICR409946 binds to DCAF1, induces head-to-tail homodimerization, sterically blocks the Vpr binding interface, prevents the recruitment of Vpr to the CRL4DCAF1 complex, and inhibits Vpr-dependent HIV replication. OICR409946 can be used in studies related to HIV infection (DCAF1 ligand: (HY-169390); Linker: (HY-130659)).
    OICR409946